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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
13/09/2017 |
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Actualizado : |
06/12/2018 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
BERTON, MP.; DE OLIVEIRA SILVA, RM.; PERIPOLLI, E.; STAFUZZA ,NB.; MARTIN, JF.; ÁLVAREZ, MS.; GAVINÃ, BV.; TORO, MA.; BANCHERO, G.; OLIVEIRA ,PS.; ELER, JP.; BALDI, F.; FERRAZ, JB. |
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Afiliación : |
Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA, Madrid, España.; Departamento de Producción Agraria, School of Agricultural, Food and Byosystems Engineering, Universisdad Politécnica de Madrid, España.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Faculdade de Zootecnia e Engenharia de Alimentos, Nucleo de Apoio à Pesquisa em Melhoramento Animal, Biotecnologia e Transgenia, Universidade de São Paulo, Brasil.; Faculdade de Zootecnia e Engenharia de Alimentos, Nucleo de Apoio à Pesquisa em Melhoramento Animal, Biotecnologia e Transgenia, Universidade de São Paulo, Brasil.; FERNANDO BALDI, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Brazil.; Faculdade de Zootecnia e Engenharia de Alimentos, Nucleo de Apoio à Pesquisa em Melhoramento Animal, Biotecnologia e Transgenia, Universidade de São Paulo,Brasil. |
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Título : |
Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate. |
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Fecha de publicación : |
2017 |
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Fuente / Imprenta : |
Journal of Animal Science and Biotechnology , v.8.p. 73.OPEN ACCESS. |
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Descripción física : |
Received: 7 December 2016 Accepted: 12 June 2017 Published: 4 September 2017. |
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DOI : |
10.1186/s40104-017-0190-4 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 7 December 2016 //Accepted: 12 June 2017 //Published: 4 September 2017. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Contenido : |
Abstract
Background: The aim of this study was to estimate variance components and to identify genomic regions and
pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in a breed of
sheep adapted to tropical climate. Phenotypes evaluations were performed to verify resistance to gastrointestinal
parasites, and were divided into two categories: i) farm phenotypes, assessing body condition score (BCS), degree
of anemia assessed by the famacha chart (FAM), fur score (FS) and feces consistency (FC); and ii) lab phenotypes,
comprising blood analyses for hematocrit (HCT), white blood cell count (WBC), red blood cell count (RBC),
hemoglobin (HGB), platelets (PLT) and transformed (log10) egg per gram of feces (EPGlog). A total of 576 animals
were genotyped with the Ovine SNP12k BeadChip (Illumina, Inc.), that contains 12,785 bialleleic SNP markers. The
variance components were estimated using a single trait model by single step genomic BLUP procedure.
Results: The overall linkage disequilibrium (LD) mean between pairs of markers measured by r
2 was 0.23. The overall
LD mean between markers considering windows up to 10 Mb was 0.07. The mean LD between adjacent SNPs across
autosomes ranged from 0.02 to 0.10. Heritability estimates were low for EPGlog (0.11), moderate for RBC (0.18), PLT (0.
17) HCT (0.20), HGB (0.16) and WBC (0.22), and high for FAM (0.35). A total of 22, 21, 23, 20, 26, 25 and 23 windows for
EPGlog for FAM, WBC, RBC, PLT, HCT and HGB traits were identified, respectively. Among the associated windows, 10
were shown to be common to HCT and HGB traits on OAR1, OAR2, OAR3, OAR5, OAR8 and OAR15.
Conclusion: The traits indicating gastrointestinal parasites resistance presented an adequate genetic variability to
respond to selection in Santa Inês breed, and it is expected a higher genetic gain for FAM trait when compared to the
others. The level of LD estimated for markers separated by less than 1 Mb indicated that the Ovine SNP12k BeadChip
might be a suitable tool for identifying genomic regions associated with traits related to gastrointestinal parasite
resistance. Several candidate genes related to immune system development and activation, inflammatory response,
regulation of lymphocytes and leukocytes proliferation were found. These genes may help in the selection of animals
with higher resistance to parasites. MenosAbstract
Background: The aim of this study was to estimate variance components and to identify genomic regions and
pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in a breed of
sheep adapted to tropical climate. Phenotypes evaluations were performed to verify resistance to gastrointestinal
parasites, and were divided into two categories: i) farm phenotypes, assessing body condition score (BCS), degree
of anemia assessed by the famacha chart (FAM), fur score (FS) and feces consistency (FC); and ii) lab phenotypes,
comprising blood analyses for hematocrit (HCT), white blood cell count (WBC), red blood cell count (RBC),
hemoglobin (HGB), platelets (PLT) and transformed (log10) egg per gram of feces (EPGlog). A total of 576 animals
were genotyped with the Ovine SNP12k BeadChip (Illumina, Inc.), that contains 12,785 bialleleic SNP markers. The
variance components were estimated using a single trait model by single step genomic BLUP procedure.
Results: The overall linkage disequilibrium (LD) mean between pairs of markers measured by r
2 was 0.23. The overall
LD mean between markers considering windows up to 10 Mb was 0.07. The mean LD between adjacent SNPs across
autosomes ranged from 0.02 to 0.10. Heritability estimates were low for EPGlog (0.11), moderate for RBC (0.18), PLT (0.
17) HCT (0.20), HGB (0.16) and WBC (0.22), and high for FAM (0.35). A total of 22, 21, 23, 20, 26, 25 and 23 windows for
EPGlog for FAM, WBC, RBC, PL... Presentar Todo |
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Palabras claves : |
GWAS; LINKAGE DISEQUILIBRIUM; PARASITES RESISTANCE; RESISTENCIA A PARÁSITOS GASTROINTESTINALES; SANTA INES BREED. |
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Thesagro : |
ENFERMEDADES DE LOS ANIMALES. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12142/1/Berton-MP.-2017.-Jr.-Animal-Sc.-Biotech..pdf
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Marc : |
LEADER 03896naa a2200373 a 4500
001 1057561
005 2018-12-06
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1186/s40104-017-0190-4$2DOI
100 1 $aBERTON, MP.
245 $aGenomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate.$h[electronic resource]
260 $c2017
300 $cReceived: 7 December 2016 Accepted: 12 June 2017 Published: 4 September 2017.
500 $aArticle history: Received: 7 December 2016 //Accepted: 12 June 2017 //Published: 4 September 2017. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
520 $aAbstract Background: The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in a breed of sheep adapted to tropical climate. Phenotypes evaluations were performed to verify resistance to gastrointestinal parasites, and were divided into two categories: i) farm phenotypes, assessing body condition score (BCS), degree of anemia assessed by the famacha chart (FAM), fur score (FS) and feces consistency (FC); and ii) lab phenotypes, comprising blood analyses for hematocrit (HCT), white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), platelets (PLT) and transformed (log10) egg per gram of feces (EPGlog). A total of 576 animals were genotyped with the Ovine SNP12k BeadChip (Illumina, Inc.), that contains 12,785 bialleleic SNP markers. The variance components were estimated using a single trait model by single step genomic BLUP procedure. Results: The overall linkage disequilibrium (LD) mean between pairs of markers measured by r 2 was 0.23. The overall LD mean between markers considering windows up to 10 Mb was 0.07. The mean LD between adjacent SNPs across autosomes ranged from 0.02 to 0.10. Heritability estimates were low for EPGlog (0.11), moderate for RBC (0.18), PLT (0. 17) HCT (0.20), HGB (0.16) and WBC (0.22), and high for FAM (0.35). A total of 22, 21, 23, 20, 26, 25 and 23 windows for EPGlog for FAM, WBC, RBC, PLT, HCT and HGB traits were identified, respectively. Among the associated windows, 10 were shown to be common to HCT and HGB traits on OAR1, OAR2, OAR3, OAR5, OAR8 and OAR15. Conclusion: The traits indicating gastrointestinal parasites resistance presented an adequate genetic variability to respond to selection in Santa Inês breed, and it is expected a higher genetic gain for FAM trait when compared to the others. The level of LD estimated for markers separated by less than 1 Mb indicated that the Ovine SNP12k BeadChip might be a suitable tool for identifying genomic regions associated with traits related to gastrointestinal parasite resistance. Several candidate genes related to immune system development and activation, inflammatory response, regulation of lymphocytes and leukocytes proliferation were found. These genes may help in the selection of animals with higher resistance to parasites.
650 $aENFERMEDADES DE LOS ANIMALES
653 $aGWAS
653 $aLINKAGE DISEQUILIBRIUM
653 $aPARASITES RESISTANCE
653 $aRESISTENCIA A PARÁSITOS GASTROINTESTINALES
653 $aSANTA INES BREED
700 1 $aDE OLIVEIRA SILVA, RM.
700 1 $aPERIPOLLI, E.
700 1 $aSTAFUZZA ,NB.
700 1 $aMARTIN, JF.
700 1 $aÁLVAREZ, MS.
700 1 $aGAVINÃ, BV.
700 1 $aTORO, MA.
700 1 $aBANCHERO, G.
700 1 $aOLIVEIRA ,PS.
700 1 $aELER, JP.
700 1 $aBALDI, F.
700 1 $aFERRAZ, JB.
773 $tJournal of Animal Science and Biotechnology$gv.8.p. 73.OPEN ACCESS.
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Registro original : |
INIA La Estanzuela (LE) |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas; INIA Treinta y Tres. |
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Fecha actual : |
11/09/2014 |
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Actualizado : |
04/11/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
A - 2 |
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Autor : |
BONNECARRERE, V.; BORSANI, O.; DIAZ, P.; CAPDEVIELLE, F.; BLANCO, P.H.; MONZA, J. |
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Afiliación : |
MARIA VICTORIA BONNECARRERE MARTINEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAOLA ALEXANDRA DIAZ DELLAVALLE, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; FABIAN MARCEL CAPDEVIELLE SOSA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; PEDRO HORACIO BLANCO BARRAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Response to photoxidative stress induced by cold in japonica rice is genotype dependent. |
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Fecha de publicación : |
2011 |
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Fuente / Imprenta : |
Plant Science, 2011, 180 (5): 726-732. |
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Volumen : |
180 |
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Páginas : |
p.726-732 |
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ISSN : |
0168-9452 |
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DOI : |
10.1016/j.plantsci.2011.01.023 |
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Idioma : |
Inglés |
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Notas : |
Article history: received 25 November 2010; received in revised form 27 January 2011; accepted 31 January 2011; available online 15 February 2011. |
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Contenido : |
ABSTRACT.
Two japonica rice genotypes, INIA Tacuarí and L2825CA, were analyzed for tolerance to low temperature during early vegetative growth. Effect on photosynthesis, energy dissipation, pigment content, xanthophyll-cycle pool conversion, hydrogen peroxide accumulation, oxidative damage and antioxidant enzyme activities were determined to better understand potential mechanisms for cold tolerance. Photoinhibition was measured using chlorophyll fluorescence and oxidative damage by lipid peroxidation and electrolyte leakage. Both genotypes were demonstrated to be cold tolerant which was consistent with their reduced levels of photoinhibition and oxidative damage compared with a cold-sensitive genotype during chilling stress. The strategy for cold tolerance differed between the two genotypes, and involved different mechanisms for disposal of excess energy. The presence of high lutein concentrations and the existence of active non-harmful energy dissipation processes through the xanthophyll cycle appeared to be responsible for chilling tolerance in INIA Tacuarí. On the other hand, increased cold tolerance of L2825CA relative to INIA Tacuarí was related to the higher constitutive superoxide dismutase (SOD, EC 1.15.1.1), ascorbate peroxidase (APX, EC 1.11.1.11) and catalase (CAT, EC 1.11.1.6). |
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Palabras claves : |
ANTIOXIDANT ENZYMES; CHILLING; ENERGY DISSIPATION; OXIDATIVE STRESS; PHOTOINHIBITION. |
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Thesagro : |
ARROZ; FITOMEJORAMIENTO; INIA TACUARI; TOLERANCIA A FRIO. |
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Asunto categoría : |
F30 Genética vegetal y fitomejoramiento |
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Marc : |
LEADER 02400naa a2200349 a 4500
001 1012830
005 2019-11-04
008 2011 bl uuuu u00u1 u #d
022 $a0168-9452
024 7 $a10.1016/j.plantsci.2011.01.023$2DOI
100 1 $aBONNECARRERE, V.
245 $aResponse to photoxidative stress induced by cold in japonica rice is genotype dependent.$h[electronic resource]
260 $c2011
300 $ap.726-732 180
490 $v180
500 $aArticle history: received 25 November 2010; received in revised form 27 January 2011; accepted 31 January 2011; available online 15 February 2011.
520 $aABSTRACT. Two japonica rice genotypes, INIA Tacuarí and L2825CA, were analyzed for tolerance to low temperature during early vegetative growth. Effect on photosynthesis, energy dissipation, pigment content, xanthophyll-cycle pool conversion, hydrogen peroxide accumulation, oxidative damage and antioxidant enzyme activities were determined to better understand potential mechanisms for cold tolerance. Photoinhibition was measured using chlorophyll fluorescence and oxidative damage by lipid peroxidation and electrolyte leakage. Both genotypes were demonstrated to be cold tolerant which was consistent with their reduced levels of photoinhibition and oxidative damage compared with a cold-sensitive genotype during chilling stress. The strategy for cold tolerance differed between the two genotypes, and involved different mechanisms for disposal of excess energy. The presence of high lutein concentrations and the existence of active non-harmful energy dissipation processes through the xanthophyll cycle appeared to be responsible for chilling tolerance in INIA Tacuarí. On the other hand, increased cold tolerance of L2825CA relative to INIA Tacuarí was related to the higher constitutive superoxide dismutase (SOD, EC 1.15.1.1), ascorbate peroxidase (APX, EC 1.11.1.11) and catalase (CAT, EC 1.11.1.6).
650 $aARROZ
650 $aFITOMEJORAMIENTO
650 $aINIA TACUARI
650 $aTOLERANCIA A FRIO
653 $aANTIOXIDANT ENZYMES
653 $aCHILLING
653 $aENERGY DISSIPATION
653 $aOXIDATIVE STRESS
653 $aPHOTOINHIBITION
700 1 $aBORSANI, O.
700 1 $aDIAZ, P.
700 1 $aCAPDEVIELLE, F.
700 1 $aBLANCO, P.H.
700 1 $aMONZA, J.
773 $tPlant Science, 2011, 180 (5): 726-732.
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